Clinical efficacy of metagenomic next-generation sequencing for the detection of pathogens in peritoneal dialysis-related peritonitis: a prospective cohort study
This study revealed that mNGS exhibited higher sensitivity and shorter reporting time compared to culture in detecting pathogens in PD-related peritonitis. For samples that yielded positive results by both methods, the consistency between mNGS and culture was substantial. mNGS may offer a novel approach for the etiological diagnosis of PD-associated peritonitis, particularly in cases involving prior antibiotic use and unusual pathogens.
Authors
- Yangyang Xia (ORCID: https://orcid.org/0000-0002-5754-0062)
- Bo Jin (ORCID: https://orcid.org/0000-0002-8958-4019)
- Pengfei Xu (ORCID: https://orcid.org/0000-0001-6854-6040)
- Qiuyuan Shao (ORCID: https://orcid.org/0000-0001-7314-1275)
- Yuan Feng (ORCID: https://orcid.org/0000-0001-5481-3865)
- Min Zhao (ORCID: https://orcid.org/0000-0002-9888-4443)
- Sixiu Liu (ORCID: https://orcid.org/0000-0002-7416-9285)
- Jing Liu (ORCID: https://orcid.org/0000-0001-8802-0783)
- Chunming Jiang (ORCID: https://orcid.org/0000-0002-5934-6570)
- Qingyan Zhang (ORCID: https://orcid.org/0000-0002-7477-9657)
- Tianfeng Tang
Institutions
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1186/s40001-025-02322-y
- Citations
- 2
- Primary Topic
- Dialysis and Renal Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 2.86