Simvastatin ameliorates senescence-induced mitochondrial dysfunction in vascular smooth muscle cells
Our results suggest that simvastatin controls SASP and exerts potentially beneficial therapeutic effects by ameliorating senescence-induced mitochondrial dysfunction in senescent VSMCs.
Authors
- M. Ruscica
- Clara Rossi (ORCID: https://orcid.org/0000-0002-6403-2533)
- Marco Venturin (ORCID: https://orcid.org/0000-0002-5871-9689)
- C Macchi
- Stefano Bellosta (ORCID: https://orcid.org/0000-0001-5344-7824)
- Alberto Corsini (ORCID: https://orcid.org/0000-0002-9912-9482)
- Camilla D'Alonzo
- Cristina Battaglia (ORCID: https://orcid.org/0000-0003-3025-9657)
Institutions
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
Publication Details
- Journal
- Atherosclerosis
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1016/j.atherosclerosis.2025.119176
- Citations
- 3
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- European Commission
- Ministero dell'Università e della Ricerca