Elevated levels of aquaporin-4-containing extracellular vesicles in cerebrospinal fluid of patients with bipolar disorder
Our findings revealed significantly more EVs expressing the three AQP4 epitopes in patients with bipolar disorder compared with healthy controls. This suggests a dysregulated expression of AQP4, implicating a potential disruption in brain water homeostasis as a contributing pathogenic mechanism in bipolar disorder.
Authors
- Lennart Wetterberg (ORCID: https://orcid.org/0000-0001-7656-7458)
- Håkan Wallén (ORCID: https://orcid.org/0000-0002-0927-7343)
- Mikael Landén (ORCID: https://orcid.org/0000-0002-4496-6451)
- Dietrich von Rosen (ORCID: https://orcid.org/0000-0002-3135-4325)
- Fariborz Mobarrez (ORCID: https://orcid.org/0000-0002-7106-6248)
- Aurimantas Pelanis
- Rolf Nybom
Institutions
- Linköping University (SE)
- Uppsala University Hospital (SE)
- Sahlgrenska University Hospital (SE)
- Karolinska Institutet (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Upsala Journal of Medical Sciences
- Published
- 2025-03-22
- DOI
- https://doi.org/10.48101/ujms.v130.12006
- Citations
- 2
- Primary Topic
- Adolescent and Pediatric Healthcare
- Type
- article
- Field-Weighted Citation Impact
- 6.24