Surface charge of the C-terminal helix is crucial for antibacterial activity of endolysin against Gram-negative bacteria
The antibacterial activity of endolysin against Gram-negative bacteria could be enhanced by adjusting the surface charge on the C-terminal amphipathic helix to more positive, suggesting that the positive surface charge on the C-terminal amphipathic helix of endolysin is crucial for its penetration of outer membrane to reach peptidoglycan layer of Gram-negative bacteria.
Authors
- Eunbyeol Ahn (ORCID: https://orcid.org/0009-0004-9926-5996)
- Su Min Son
- Haejoon Park
- Sangryeol Ryu (ORCID: https://orcid.org/0000-0001-5812-3394)
- Joonbeom Kim (ORCID: https://orcid.org/0009-0007-2119-0789)
Institutions
- Seoul National University (KR)
- Biocon (Switzerland) (CH)
- National University College (PR)
- Nkmax (South Korea) (KR)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1186/s12929-025-01133-x
- Citations
- 2
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 3.43
Funders
- Rural Development Administration
- Korea Health Industry Development Institute
- National Research Foundation of Korea