70P Optimizing second-line therapy for advanced gastrointestinal stromal tumors: Real-world efficacy and safety analysis
Ripretinib has emerged as a promising second-line therapy for patients with unresectable or metastatic gastrointestinal stromal tumors (GISTs), demonstrating comparable efficacy to sunitinib and a superior safety profile. However, the optimal second-line therapy tailored to individual patient characteristics remains underexplored. This prospective, multicenter, observational study (NCT05440357) aims to evaluate real-world patterns and outcomes for GISTs patients.
Authors
- Xiaodong Feng (ORCID: https://orcid.org/0000-0002-2741-5420)
- Lijun Fan (ORCID: https://orcid.org/0000-0001-5863-0169)
- Aiping Chen
- J. Zhang
- Yuwei Xia (ORCID: https://orcid.org/0000-0002-2248-2296)
- Z. Li
- Yan Yin (ORCID: https://orcid.org/0000-0002-5255-2064)
- Zi‐Niu Ding (ORCID: https://orcid.org/0000-0001-8995-6612)
- Lingling Wang (ORCID: https://orcid.org/0000-0003-0272-2974)
- Min Wang (ORCID: https://orcid.org/0000-0001-9670-6937)
- Xu Che (ORCID: https://orcid.org/0000-0003-4193-3264)
- Hongrui Wang (ORCID: https://orcid.org/0000-0002-2916-8849)
- Xin Wu (ORCID: https://orcid.org/0000-0002-3839-4768)
- Huiying Sun (ORCID: https://orcid.org/0000-0001-8916-9387)
- Yun Jin (ORCID: https://orcid.org/0000-0001-7750-1370)
- Yiqiang Liu (ORCID: https://orcid.org/0000-0002-7239-2360)
- Meng Pang (ORCID: https://orcid.org/0000-0003-4657-3990)
- Xiangjian Zhang (ORCID: https://orcid.org/0000-0003-0114-1668)
- Min Liu (ORCID: https://orcid.org/0000-0001-8115-5407)
Institutions
- Sun Yat-sen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Fuyang City People's Hospital (CN)
- Deyang Stomatological Hospital (CN)
- Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN)
- Sichuan Cancer Hospital (CN)
- Fuzhou General Hospital of Nanjing Military Command (CN)
- Peking University Shenzhen Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chengdu Fifth People's Hospital (CN)
- Taiyuan Central Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
- Guangdong Provincial People's Hospital (CN)
- Chongqing Cancer Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.esmoop.2025.104384
- Primary Topic
- Gastrointestinal Tumor Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00