Single-Cell Transcriptomics Identifies a Prominent Role for the MIF-CD74 Axis in Myasthenia Gravis Thymus
Our data not only illustrate and define hyperplastic thymic niches in MG as favorable environments for pathogenic B-cell proliferation, maturation, and persistence but also suggest that the MIF-CD74 axis should be investigated for potential novel therapeutic targeting in EOMG.
Authors
- Ronja Mothes (ORCID: https://orcid.org/0000-0001-6583-1567)
- Nick Willcox (ORCID: https://orcid.org/0000-0003-2380-7686)
- Helena Radbruch (ORCID: https://orcid.org/0000-0001-6941-3397)
- Christian W. Keller (ORCID: https://orcid.org/0000-0003-2276-0003)
- Jan D. Lünemann (ORCID: https://orcid.org/0000-0002-3007-708X)
- Michael Heming (ORCID: https://orcid.org/0000-0002-9568-2790)
- Heinz Wiendl (ORCID: https://orcid.org/0000-0003-4310-3432)
- Isaak Quast (ORCID: https://orcid.org/0000-0001-6517-8537)
- Frauke Stascheit (ORCID: https://orcid.org/0000-0001-5306-7880)
- Andreas Meisel (ORCID: https://orcid.org/0000-0001-7233-5342)
- I‐Na Lu (ORCID: https://orcid.org/0000-0002-3845-7386)
- Anja E. Hauser (ORCID: https://orcid.org/0000-0002-7725-9526)
- Gerd Meyer zu Hörste (ORCID: https://orcid.org/0000-0002-4341-4719)
- Lennard Ostendorf (ORCID: https://orcid.org/0000-0003-3553-6406)
- Paula Terroba-Navajas
Institutions
- University Medical Center Freiburg (DE)
- Leibniz Association (DE)
- Humboldt-Universität zu Berlin (DE)
- German Rheumatism Research Centre (DE)
- University Hospital Münster (DE)
- MRC Weatherall Institute of Molecular Medicine (GB)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Monash University (AU)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1212/nxi.0000000000200384
- Citations
- 5
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 3.99