Ginsenoside Rb2 demonstrates potent antiviral activity against Zika virus infection
G-Rb2 effectively inhibits ZIKV infection both <i>in vitro</i> and <i>in vivo</i>, presumably through direct interaction with viral particles. Given the accessibility of ginseng and its established processing methods, G-Rb2 emerges as a promising candidate for the treatment of ZIKV in humans. Further research is warranted to elucidate its mechanisms of action and evaluate its clinical potential.
Authors
- Yuanjiu Miao (ORCID: https://orcid.org/0000-0002-6199-6038)
- Zhongyuan Tan (ORCID: https://orcid.org/0000-0003-1408-5239)
- Zhenhua Zheng (ORCID: https://orcid.org/0000-0002-4117-9364)
- H Chen
- Ting Wang (ORCID: https://orcid.org/0000-0003-4654-5869)
- Ning Chen (ORCID: https://orcid.org/0000-0003-1587-3456)
- Tong Wu (ORCID: https://orcid.org/0000-0002-9878-4821)
Institutions
- Wuhan Institute of Virology (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Wuhan Sports University (CN)
Publication Details
- Journal
- Journal of Ginseng Research
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1016/j.jgr.2025.03.007
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Hubei Province
- National Key Research and Development Program of China