EXPERIMENTAL STUDY ON THE HEALING EFFECT OF PINE RESIN ON SKIN WOUNDS IN RATS

The skin is the largest organ in the body and is constantly exposed to trauma. Many agents and methods have been tried from past to present to accelerate healing in skin injuries. Today, the use of herbal origin agents is gaining popularity. Resins are known to have anti-inflammatory, antibacterial, antifungal and antioxidant properties. In our study, we examined the effect of resins obtained from pine trees on wound healing. In the study, 3 groups were formed as pine resin group, control group and antibiotic group, with 7 animals in each group (21 animals in total). All animals were photographed once a day for 15 days in terms of wound dimensions and wound area measurements were performed digitally with ImageJ program. At the end of the 15th day, the animals were euthanized and histopathological examination was performed. As a result of the study, local pine resin application showed a greater improvement in terms of wound area in the first three days compared to the antibiotic and control group, while the antibiotic and pine resin group showed similar improvement on days 3-15 and showed more improvement compared to the control group. When examined histopathologically, pine resin and antibiotic groups showed similar effects and increased epithelialization, inflammatory cell infiltration and granulation cell formation.