Effects of photobiomodulation therapy with 808 nm diode laser on the expression of RANKL and OPG genes in exosomes isolated from MG63 osteoblast-like cells: An in-vitro study
Using 808 nm diode laser at an energy density of 9 J/cm² resulted in an upregulation of exosomal mRNA for OPG and a downregulation of RANKL. Photobiomodulation may enhance bone regeneration via exosomal signaling. Considering the promising clinical application of exosomes in bone regeneration, our results highlight the potential of photobiomodulation to manipulate exosomal content for therapeutic purposes.
Authors
- Maryam Pourhajibagher (ORCID: https://orcid.org/0000-0002-2772-8136)
- Ferial Taleghani (ORCID: https://orcid.org/0000-0002-4348-0759)
- Maryam Tehranchi (ORCID: https://orcid.org/0000-0002-0759-4951)
- Mahshid Hodjat (ORCID: https://orcid.org/0000-0001-8335-3546)
- Neda Hakimiha (ORCID: https://orcid.org/0000-0001-5188-0325)
- Sara Noorizadeh
Institutions
- Shahed University (IR)
- Aja University of Medical Sciences (IR)
- Sina Hospital (IR)
- Shahid Beheshti University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Photodiagnosis and Photodynamic Therapy
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1016/j.pdpdt.2025.104566
- Citations
- 4
- Primary Topic
- Laser Applications in Dentistry and Medicine
- Type
- article
- Field-Weighted Citation Impact
- 5.44
Funders
- Shahed University