Electroacupuncture at 5/100 Hz alleviates neuropathic pain in rats by inhibiting the CCL3/CCR5 axis in the spinal cord
EA may mitigate chronic NP in rats by blocking the CCL3/CCR5 axis in the spinal cord. In addition, EA appeared to exert anti-inflammatory and analgesic effects by suppressing glial cell activation. These findings add to our understanding of the mechanism of EA-induced analgesia.
Authors
- Chengcheng Zhou (ORCID: https://orcid.org/0000-0003-3958-5360)
- Min Zhong (ORCID: https://orcid.org/0000-0002-8759-7983)
- Xiuju Yin
- Feng Wang (ORCID: https://orcid.org/0000-0001-5993-9037)
- Ye Zhihui (ORCID: https://orcid.org/0000-0001-6610-9787)
- Gaofeng Zhao (ORCID: https://orcid.org/0000-0002-7322-6604)
Institutions
- Guangzhou University of Chinese Medicine (CN)
Publication Details
- Journal
- Acupuncture in Medicine
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1177/09645284251327197
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Guangdong Province