Investigation of the HLA locus in autopsy-confirmed progressive supranuclear palsy
Our study suggests that epitopes within the tau peptide may bind to HLA alleles that are found in a subset of PSP patients supporting the notion of an autoimmune pathophysiological component. These findings have implications for subtyping and stratifying patients for therapies, including those targeting immune modulation.
Authors
- Anthony E. Lang (ORCID: https://orcid.org/0000-0003-1229-3667)
- Subha Kalyaanamoorthy (ORCID: https://orcid.org/0000-0003-0854-6449)
- Hidetomo Tanaka
- Gábor G. Kovács
- Ekaterina A. Rogaeva (ORCID: https://orcid.org/0000-0002-2852-0329)
- Sathish Dasari (ORCID: https://orcid.org/0000-0002-5554-9047)
- Maria Carmela Tartaglia (ORCID: https://orcid.org/0000-0002-5944-8497)
- Susan Helen Fox (ORCID: https://orcid.org/0009-0004-7568-1645)
- Shelley L. Forrest
- Jinguo Wang (ORCID: https://orcid.org/0000-0002-5213-8314)
Institutions
- University Health Network (CA)
- University of Waterloo (CA)
- University of Toronto (CA)
- Toronto Western Hospital (CA)
- Occupational Cancer Research Centre (CA)
Publication Details
- Journal
- Immunobiology
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1016/j.imbio.2025.152892
- Citations
- 4
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.56