Obese Adipose Tissue Extracellular Vesicles Activate Mitochondrial Fatty Acid β-oxidation to Drive Colonic Stemness
The contents of Ob EVs are poised to fuel FAO and to promote obesity-induced stemness in the colon. Alteration of metabolism is a key mechanism of adipose-to-intestinal tissue communication elicited by EVs, thereby influencing basal colonic stem cell homeostasis during obesity.
Authors
- Christina Coughlan (ORCID: https://orcid.org/0000-0002-7229-7056)
- Parsa Haque (ORCID: https://orcid.org/0000-0001-9544-1519)
- Janos Zempleni (ORCID: https://orcid.org/0000-0001-5492-4661)
- Arianne L. Theiss (ORCID: https://orcid.org/0000-0003-2862-0933)
- Yaritza Delgado‐Deida
- Joseph C. Onyiah
- DeWitt S. Goodman
- Thor Kuusivuori-Robinson
Institutions
- University of Nebraska–Lincoln (US)
- Rocky Mountain MS Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101504
- Citations
- 1
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- U.S. Department of Veterans Affairs
- Crohn's and Colitis Foundation
- National Institute of Food and Agriculture
- National Cancer Institute
- National Institute of General Medical Sciences
- National Institute of Diabetes and Digestive and Kidney Diseases
- Division of Cancer Epidemiology and Genetics, National Cancer Institute