APOE Drives Glioma Progression by Modulating CCL5/CCR5 Signaling in the Tumor Microenvironment and Inducing M2 Macrophage Polarization
Our findings indicate that APOE knockdown suppresses glioblastoma cell migration, invasion, and CCL5 secretion, while enhancing the production of tumor-suppressive cytokines.
Authors
- Wei Huang
- Chengwei Xiang
- Weimin Li (ORCID: https://orcid.org/0000-0003-0985-0311)
- Xingyu Chen (ORCID: https://orcid.org/0009-0005-1343-0231)
- Ke Luo (ORCID: https://orcid.org/0000-0002-2624-0323)
Institutions
- Suizhou Central Hospital (CN)
Publication Details
- Journal
- Immunobiology
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1016/j.imbio.2025.152895
- Citations
- 5
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.99