Age- and sex-specific reference values of estimated glomerular filtration rate for European adults

Kidney function, often assessed by estimated glomerular filtration rate (eGFR), declines naturally with age. However, there is a lack of eGFR reference values to describe normal and abnormal values for a specific age. The European Chronic Kidney Disease Burden Consortium is comprised of nine participating general population-based studies from seven European countries which provides European age- and sex-specific eGFR reference values in healthy adults using the European Kidney Function Consortium (EKFC) equation. Of 2,572,020 individuals, 1,535,253 (60%) were considered healthy, of which 45% were men. Ages ranged from 18 to 105 years old in men and 18 to 107 years old in women with a median age of 43 years in both sexes. At age 20 in men, the 5<sup>th</sup>, 50<sup>th</sup> and 95<sup>th</sup> eGFR percentiles were 78 ml/min per 1.73 m<sup>2</sup>, 99 ml/min per 1.73 m<sup>2</sup>, and 119 ml/min per 1.73 m<sup>2</sup>. In 20-year-old women this was 81 ml/min per 1.73 m<sup>2</sup>, 101 ml/min per 1.73 m<sup>2</sup>, and 121 ml/min per 1.73 m<sup>2</sup>. Consequently, in men aged 80 years old, the 5<sup>th</sup>, 50<sup>th</sup> and 95<sup>th</sup> eGFR percentiles were 49 ml/min per 1.73 m<sup>2</sup>, 66 ml/min per 1.73 m<sup>2</sup>, and 84 ml/min per 1.73 m<sup>2</sup>. In 80 year old women this was 46 ml/min per 1.73 m<sup>2</sup>, 63 ml/min per 1.73 m<sup>2</sup>, and 81 ml/min per 1.73 m<sup>2</sup>. Overall, our study shows that eGFR is not preserved with ageing in healthy individuals and these eGFR reference values can help determine abnormal and normal kidney function across the age range.

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Publication Details

Journal
Kidney International
Published
2025-03-22
DOI
https://doi.org/10.1016/j.kint.2025.02.025
Citations
20
Primary Topic
Chronic Kidney Disease and Diabetes
Type
article
Field-Weighted Citation Impact
28.62

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article

Age- and sex-specific reference values of estimated glomerular filtration rate for European adults

Megan E Astley, Stein Hallan, Natalie Ebert, Anne‐Laure Faucon et al.
20 citations
Kidney International
Chronic Kidney Disease and Diabetes
28.62
article

Age- and sex-specific reference values of estimated glomerular filtration rate for European adults

Megan E Astley, Stein Hallan, Natalie Ebert, Anne‐Laure Faucon, Nicholas C Chesnaye, Toralf Melsom, Sylvia Stracke, Elke Schäeffner, Giovanni Gambaro, Kitty J. Jager, Juan Jesús Carrero, Vianda S Stel, Knut Asbjørn Rise Langlo, Alberto Ortíz, Arnar J. Jonsson, Till Ittermann, Ólafur S. Indridason, Björn O. Eriksen, Pietro Manuel Ferraro
article en
20 citations

Abstract

Kidney function, often assessed by estimated glomerular filtration rate (eGFR), declines naturally with age. However, there is a lack of eGFR reference values to describe normal and abnormal values for a specific age. The European Chronic Kidney Disease Burden Consortium is comprised of nine participating general population-based studies from seven European countries which provides European age- and sex-specific eGFR reference values in healthy adults using the European Kidney Function Consortium (EKFC) equation. Of 2,572,020 individuals, 1,535,253 (60%) were considered healthy, of which 45% were men. Ages ranged from 18 to 105 years old in men and 18 to 107 years old in women with a median age of 43 years in both sexes. At age 20 in men, the 5<sup>th</sup>, 50<sup>th</sup> and 95<sup>th</sup> eGFR percentiles were 78 ml/min per 1.73 m<sup>2</sup>, 99 ml/min per 1.73 m<sup>2</sup>, and 119 ml/min per 1.73 m<sup>2</sup>. In 20-year-old women this was 81 ml/min per 1.73 m<sup>2</sup>, 101 ml/min per 1.73 m<sup>2</sup>, and 121 ml/min per 1.73 m<sup>2</sup>. Consequently, in men aged 80 years old, the 5<sup>th</sup>, 50<sup>th</sup> and 95<sup>th</sup> eGFR percentiles were 49 ml/min per 1.73 m<sup>2</sup>, 66 ml/min per 1.73 m<sup>2</sup>, and 84 ml/min per 1.73 m<sup>2</sup>. In 80 year old women this was 46 ml/min per 1.73 m<sup>2</sup>, 63 ml/min per 1.73 m<sup>2</sup>, and 81 ml/min per 1.73 m<sup>2</sup>. Overall, our study shows that eGFR is not preserved with ageing in healthy individuals and these eGFR reference values can help determine abnormal and normal kidney function across the age range.

Kidney InternationalVol. 107(6)
University of Verona (IT), Reykjavík University (IS), University Hospital of North Norway (NO), Inserm (FR), University of Iceland (IS), Norwegian University of Science and Technology (NO), Université Paris-Saclay (FR), Universitätsmedizin Greifswald (DE), Danderyds sjukhus (SE), Glanrhyd Hospital (GB), Centre de recherche en Epidémiologie et Santé des Populations (FR), St Olav's University Hospital (NO), National University Hospital of Iceland (IS), Hospital Universitario Fundación Jiménez Díaz (ES), Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE), Amsterdam University Medical Centers (NL), Universidad Autónoma de Madrid (ES), Charité - Universitätsmedizin Berlin (DE), University of Amsterdam (NL)
Amgen, Eli Lilly and Company, AstraZeneca, Bayer, Sanofi, Alexion Pharmaceuticals, Amicus Therapeutics, Fresenius Medical Care North America, European Commission, Vetenskapsrådet, Astellas Pharma, Swedish Orphan Biovitrum, KfH-Stiftung Präventivmedizin, Idorsia Pharmaceuticals, Instituto de Salud Carlos III
Zero hunger
Openalex Percentile: Top 0%
Chronic Kidney Disease and Diabetes
28.62
DOIOpen Access PDFOpenAlex
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