CMTM4 promotes PD-L1-mediated macrophage apoptosis by enhancing STAT2 phosphorylation in sepsis
In sepsis, CMTM4 facilitates PD-L1-dependent macrophage apoptosis by enhancing STAT2 phosphorylation. This discovery offers new insights for the diagnosis and treatment of sepsis.
Authors
- Zhujun Yi
- Huijun Zhao (ORCID: https://orcid.org/0000-0002-3028-0459)
- Degong Jia (ORCID: https://orcid.org/0000-0002-3627-6469)
- Yan Liu
- Gong Jianping (ORCID: https://orcid.org/0000-0003-0045-4638)
- Qi Feng (ORCID: https://orcid.org/0000-0001-8724-5710)
- Gang Jiang (ORCID: https://orcid.org/0000-0003-0563-3870)
Institutions
- Qingdao University (CN)
- Chongqing University (CN)
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Affiliated Hospital of Qingdao University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Chongqing Three Gorges University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Experimental Cell Research
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1016/j.yexcr.2025.114519
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00