Blood microbiome with various diseases

Blood is considered sterile, but the 16S rRNA sequencing method has shown that the blood of healthy people contains bacterial DNA. Changes in the blood microbiome of newborns are detected when there is a suspicion of type 1 diabetes, autism, IgA nephropathy, obesity, celiac disease, and bloodstream infection. In these diseases, the blood microbiota is characterized by increased bacterial saturation and the presence of pathogenic microorganisms. The microbiota of the oral cavity and intestine is the cause of translocation and causes changes in the blood microbiota in young children. In type 1 diabetes and obesity, bacteria of the Proteobacteria type predominate (82.92%) and the levels of DNA of the Bacteroides type are reduced (4.31%). In celiac disease, the following taxa predominate in the blood: Campylobacterales, Helicobacteraceae and Bacteroides. The causative agents of bloodstream infection in premature infants with low body weight were representatives of the intestinal microbiota: Klebsiella pneumonia and Acinetobacter baumannii. Autism spectrum disorder begins during the period of intrauterine development in the presence of dihydroxy fatty acids in the umbilical cord blood. The blood microbiota of young children is a persistent infection; its activity is minimized and the persistence period is extended throughout life, starting from the moment of intrauterine development of the child. The blood microbiota is pathogenetically associated with the intestinal microbiota and significantly affects the child’s health.