The Potential Role of C4 MYH11+ Fibroblasts and the MDK-SDC2 Ligand-Receptor Pair in Lung Adenocarcinoma: Implications for Prognosis and Therapeutic Strategies
This study provided a comprehensive atlas of the LUAD tumor microenvironment, highlighted the role of the C4 MYH11+ Fibroblasts in tumor progression. It also proposed the MDK-SDC2 ligand-receptor pair as a novel mechanism, addressing a significant gap in this area of research. And presented a gene-based prognostic model as a novel perspective for research into immunotherapy and drug sensitivity in LUAD.
Authors
- Yanjie Bian
- Zhang Sheng-yi (ORCID: https://orcid.org/0009-0001-4908-5506)
- Yi Zhang (ORCID: https://orcid.org/0000-0001-9861-4681)
- Jie Yuan (ORCID: https://orcid.org/0000-0002-4210-0478)
- Hongling Jia
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Tongren Hospital (CN)
- Songjiang District Central Hospital (CN)
- United Imaging Healthcare (China) (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1016/j.tranon.2025.102364
- Citations
- 1
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 1.52