MTFR1 phosphorylation-activated adaptive mitochondrial fusion is essential for colon cancer cell survival during glucose deprivation
Our findings highlight the importance of MTFR1 in modulating mitochondrial dynamics and its potential impact on colon cancer cell survival under metabolic stress. These results suggest that MTFR1 serine 119 could be a key regulator of colon cancer cell metabolism and a potential therapeutic target for enhancing cancer cell response to metabolic challenges.
Authors
- Sifan Liu (ORCID: https://orcid.org/0000-0002-7147-1315)
- Tingting Ning (ORCID: https://orcid.org/0000-0002-9986-8023)
- Nan Zhang (ORCID: https://orcid.org/0009-0005-1392-8689)
- Shengtao Zhu
- Lu Dong
Institutions
- National Clinical Research Center for Digestive Diseases (CN)
Publication Details
- Journal
- Neoplasia
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1016/j.neo.2025.101159
- Citations
- 3
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China