Comparison of Grade 3 endometrioid type endometrial cancer with clear cell and serous type endometrial cancer in terms of clinicopathology and survival, and examination of prognostic factors affecting survival.

Aim: comparison of the similarities of grade 3 endometrioid type endometrial cancer with clear cell and serous type endometrial cancer in terms of clinicopathology and survival and examination of prognostic factors affecting survival. Material and methods: the medical records of 207 patients who were diagnosed with clear cell, serous and grade 3 endometrioid type endometrial cancer and who underwent surgery at Zekai Tahir Burak Women's Health Training and Research Hospital between June 2007 and September 2019 and at Ankara City Hospital between September 2019 and April 2022 were reviewed and their demographic, surgical and pathological features were analyzed. The patients were divided into two groups as grade 3 endometrioid type endometrial cancer and serous/clear cell endometrial cancer, and the patients were compared in terms of clinical and demographic features with univariate-multivariate analyses. Results: the mean age of the patients was 63.3±9.3 years. The rate of early stage disease in the grade 3 endometrioid group was significantly higher (66.3%-44.9%, p=0.002). In the grade 3 endometrioid group, adnexal invasion rate (13.5%-31.4%, p=0.003), uterine serosal invasion rate (10.1%-22%, p=0.023), positive cytology rate (10.1%-29.7%, p=0.001), lymph node metastasis rate (20.2%-43.2%, p=0.001) and abdominal metastasis rate (9%-28%, p=0.001) were significantly lower than in the serous/clear cell group. There was no significant difference between the two groups in terms of overall survival times of 12-18-24-36 months (p=0.910). According to the univariate analysis between the groups, there was a significant risk for overall survival in age categories (p=0.039) and stages (p=0.034). In the multivariate analysis, age over 63 and advanced stage disease were evaluated as poor prognostic factors. Conclusion: there was no significant difference in survival between grade 3 endometrial cancer and serous and clear cell endometrial cancers. Being over 63 years of age and having advanced-stage disease were considered poor prognostic factors.