COPB1 deficiency triggers osteoporosis with elevated iron stores by inducing osteoblast ferroptosis
Our data elucidate the critical role of COPB1 in maintaining bone homeostasis and demonstrate that COPB1 can directly promote bone formation, making it a potential therapeutic target for the future treatment of osteoporosis.
Authors
- Sheng Pan
- Baoshan Liu (ORCID: https://orcid.org/0000-0001-5563-2652)
- Youjia Xu (ORCID: https://orcid.org/0000-0002-9826-4324)
- Qiaocheng Zhai (ORCID: https://orcid.org/0000-0003-4532-9427)
- Gongwen Liu
- Y. Wang (ORCID: https://orcid.org/0009-0007-7315-0682)
- Jiajun Zhang (ORCID: https://orcid.org/0000-0003-4419-5359)
- Kai Huang (ORCID: https://orcid.org/0000-0002-3932-6636)
- Aifei Wang (ORCID: https://orcid.org/0000-0002-5536-590X)
- Xiao Wang (ORCID: https://orcid.org/0000-0002-3090-9894)
- Yutong Hu (ORCID: https://orcid.org/0000-0001-5339-3782)
- Ruizhi Zhang
- Xiongyi Wang
- Xieyidai Ruze
Institutions
- Nantong University (CN)
- Wenzhou Medical University (CN)
- Soochow University (CN)
- Yancheng First People's Hospital (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Suzhou Traditional Chinese Medicine Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.jot.2025.01.017
- Citations
- 7
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 10.63