Evidence of immunogenic cell death (ICD) and ICD-dependent dendritic cell activation induced by extracorporeal photopheresis in patients with leukaemic forms of cutaneous T-cell lymphoma
ECP induces ICD in malignant T cells and, to a lesser extent, in healthy T cells, facilitates DC activation. These findings suggest that ECP enhances targeted immune responses against malignant T cells in leukaemic forms of CTCL, offering new insights into its therapeutic mechanisms and potential applications in cancer immunotherapy.
Authors
- Saptaswa Dey (ORCID: https://orcid.org/0000-0001-7532-7858)
- Christoph Iselin (ORCID: https://orcid.org/0009-0005-2750-5679)
- Susanne Kimeswenger (ORCID: https://orcid.org/0000-0002-0443-8558)
- Teresa Burner
- Wolfram Hoetzenecker (ORCID: https://orcid.org/0000-0003-4710-0642)
- Angelika Lackner
- Yun‐Tsan Chang (ORCID: https://orcid.org/0000-0001-6081-9614)
- Veronika Buxhofer‐Ausch (ORCID: https://orcid.org/0000-0002-7369-9700)
- Sabine Altrichter (ORCID: https://orcid.org/0000-0001-9955-385X)
- Peter Wolf (ORCID: https://orcid.org/0000-0001-7777-9444)
- Emmanuella Guenova (ORCID: https://orcid.org/0000-0001-5478-8735)
- Stefan Aigner (ORCID: https://orcid.org/0000-0002-9511-3328)
- Marija Geroldinger‐Simić (ORCID: https://orcid.org/0000-0003-2789-1862)
- Marlene Brandner
- Yi-Chien Tsai
Institutions
- Johannes Kepler University of Linz (AT)
- Medical University of Graz (AT)
- Kepler Universitätsklinikum (AT)
- Krankenhaus der Elisabethinen (AT)
- University of Lausanne (CH)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1093/bjd/ljaf102
- Citations
- 7
- Primary Topic
- Cutaneous lymphoproliferative disorders research
- Type
- article
- Field-Weighted Citation Impact
- 14.03
Funders
- Austrian Science Fund