A cholic acid–supplemented diet suppresses very-low-density lipoprotein secretion in rats in the presence of insulin
We investigated whether dietary supplementation with cholic acid (CA) suppressed hepatic very-low-density lipoprotein (VLDL) secretion in rats. Dietary CA supplementation suppressed VLDL secretion in vivo in the presence of insulin. These results suggest that enterohepatic 12-hydroxylated bile acids further enhance insulin-induced suppression of hepatic VLDL secretion, which contributes to hepatic lipid accumulation.
Authors
- Fumika Yokoyama
- Sho Tsuyama (ORCID: https://orcid.org/0000-0003-3983-1680)
- Satoshi Ishizuka (ORCID: https://orcid.org/0000-0003-2445-8238)
Institutions
- Sapporo University (JP)
- Hokkaido University (JP)
Publication Details
- Journal
- Bioscience Biotechnology and Biochemistry
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1093/bbb/zbaf041
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35