The nucleosome remodeling and deacetylase-SWItch/sucrose non-fermentable antagonism regulates the coordinated activation of epithelial-to-mesenchymal transition and inflammation in oral cancer
Our study sheds light on the role of chromatin remodeling complexes in OSCC locoregional invasion and highlights the potential of CDK2AP1 and other members of NuRD and SWI/SNF chromatin remodeling complexes as prognostic markers and therapeutic targets.
Authors
- Adrian Biddle (ORCID: https://orcid.org/0000-0003-4371-9720)
- Pieter J. M. Leenen (ORCID: https://orcid.org/0000-0001-9860-2920)
- Francesco Tucci (ORCID: https://orcid.org/0000-0001-6247-5392)
- Carmen W.E. Embregts (ORCID: https://orcid.org/0000-0003-4710-9225)
- Rosalie Joosten
- Thierry van den Bosch (ORCID: https://orcid.org/0000-0002-7223-4565)
- Roberto Stabile (ORCID: https://orcid.org/0009-0005-4986-2204)
- Maria J. De Herdt (ORCID: https://orcid.org/0000-0003-1023-4751)
- Berdine van der Steen (ORCID: https://orcid.org/0000-0002-5343-094X)
- Riccardo Fodde (ORCID: https://orcid.org/0000-0001-9839-4324)
- José A. Hardillo (ORCID: https://orcid.org/0000-0001-5580-5613)
- Robert J. Baatenburg de Jong (ORCID: https://orcid.org/0000-0001-7236-264X)
- Mathijs Verhagen (ORCID: https://orcid.org/0000-0003-3126-8379)
- C. Peter Verrijzer (ORCID: https://orcid.org/0000-0002-6476-3264)
- Senada Koljenović (ORCID: https://orcid.org/0000-0002-5185-3455)
- Alex L. Nigg
Institutions
- Queen Mary University of London (GB)
- Erasmus MC (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1093/jnci/djaf065
- Citations
- 1
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81