Asparagine Endopeptidase Inhibition Attenuates Tissue Plasminogen Activator‐Induced Brain Hemorrhagic Transformation After Ischemic Stroke
Our findings demonstrate that AEP exacerbates HT induced by delayed tPA treatment in acute ischemic stroke by activating LRP-1, MMP2, and MMP9, which disrupts BBB integrity. We further confirmed R13 as a preventive therapy to attenuate HT induced by delayed tPA treatment in acute ischemic stroke. The present study suggests AEP inhibition may serve as a promising strategy to enhance the safety of delayed tPA thrombolysis for ischemic stroke.
Authors
- Gege Jiang
- Jing Xiong (ORCID: https://orcid.org/0000-0002-2221-5972)
- Ying Yu (ORCID: https://orcid.org/0000-0002-4084-908X)
- Keqiang Ye (ORCID: https://orcid.org/0000-0002-7657-8154)
- X. Li (ORCID: https://orcid.org/0009-0008-7455-3130)
- Zhentao Zhang (ORCID: https://orcid.org/0000-0001-6708-1472)
- Bingjie Wu
- Liqin Huang (ORCID: https://orcid.org/0000-0001-8441-4216)
- Hualong Wang (ORCID: https://orcid.org/0000-0002-5741-0313)
- Guanfeng Xie
- Shangqi Sun
Institutions
- Hebei Medical University (CN)
- Union Hospital (HK)
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1111/cns.70345
- Citations
- 7
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 6.55
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hebei Province