Clinical Impact of <scp>HLA</scp>‐<scp>B27</scp> on Juvenile Idiopathic Arthritis: Eighteen Years of Follow‐up in the Population‐Based Nordic Juvenile Idiopathic Arthritis Cohort
Clinical features related to spondylarthropathies were more common in patients who were HLA-B27 positive and associated with worse outcomes and nonremission 18 years after disease onset, particularly in men. Our results underline the adverse impact of having HLA-B27 positivity on long-term outcomes in individuals with JIA.
Authors
- Marite Rygg (ORCID: https://orcid.org/0000-0001-5190-151X)
- Maria Ekelund (ORCID: https://orcid.org/0000-0002-0348-3779)
- Ellen Dalen Arnstad (ORCID: https://orcid.org/0000-0003-0635-5198)
- Kristiina Aalto (ORCID: https://orcid.org/0000-0002-5285-0424)
- Troels Herlin (ORCID: https://orcid.org/0000-0002-6525-3207)
- Ágnes Szentpétery (ORCID: https://orcid.org/0000-0002-2962-8964)
- Charlotte Myrup (ORCID: https://orcid.org/0000-0001-6960-7466)
- Suvi Peltoniemi (ORCID: https://orcid.org/0000-0002-7648-8140)
- Anders Fasth (ORCID: https://orcid.org/0000-0002-0033-740X)
- Lillemor Berntson (ORCID: https://orcid.org/0000-0003-3962-0453)
- Ellen Nordal (ORCID: https://orcid.org/0000-0001-5041-3928)
- Veronika Rypdal (ORCID: https://orcid.org/0000-0003-3476-305X)
- Mia Glerup (ORCID: https://orcid.org/0000-0002-9128-9908)
Institutions
- Uppsala University (SE)
- University Hospital of North Norway (NO)
- Norwegian University of Science and Technology (NO)
- Levanger Hospital (NO)
- Helsinki University Hospital (FI)
- Aarhus University Hospital (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Helsinki Children's Hospital (FI)
- St Olav's University Hospital (NO)
- UiT The Arctic University of Norway (NO)
- University of Gothenburg (SE)
Publication Details
- Journal
- ACR Open Rheumatology
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/acr2.70005
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Gillbergska stiftelsen
- Uppsala Universitet
- Reumatikerförbundet