Persistent Uninterpretable or Failed Prenatal Cell‐Free DNA Screening Indicates a High‐Risk Pregnancy and is Associated With Biological Factors Interfering With cfDNA‐Analysis: A Prospective Cohort Study
Persistent uninterpretable prenatal cfDNA screening indicates a higher risk for adverse perinatal outcomes, especially in cases with LFF. Maternal autoimmune screening should be considered to identify high-risk pregnancies. A third prenatal cfDNA screening later in pregnancy can help stratify truly high-risk pregnancies and allows patients with initially uninterpretable results to make an informed decision about diagnostic testing.
Authors
- E De Langhe
- Kris Van Den Bogaert (ORCID: https://orcid.org/0000-0003-4525-5907)
- Kristel Van Calsteren (ORCID: https://orcid.org/0000-0002-2438-6783)
- Lore Lannoo (ORCID: https://orcid.org/0000-0002-6271-221X)
- L. Vancoillie
- Ilse Parijs
- Koenraad Devriendt (ORCID: https://orcid.org/0000-0002-3651-2548)
- Joris Robert Vermeesch (ORCID: https://orcid.org/0000-0002-3071-1191)
- Ann Belmans (ORCID: https://orcid.org/0000-0003-1332-2917)
- Nathalie Brison
Institutions
- Statistics Belgium (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Prenatal Diagnosis
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1002/pd.6778
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00