In silico construction of a multi-epitope vaccine (RGME-VAC/ATS-1) against the Rickettsia genus using immunoinformatics
The in silico validations suggest that our study successfully designed an innovative multi-epitope vaccine against Rickettsia, addressing the challenges posed by the elusive nature of diseases caused by this genus. We provide a promising potential for further experimental exploration and the development of targeted prevention and diagnostic strategies for these diseases.
Authors
- Pedro Henrique Marques (ORCID: https://orcid.org/0000-0002-7334-4707)
- Bruno Silva Andrade (ORCID: https://orcid.org/0000-0002-8031-9454)
- Sandeep Tiwari (ORCID: https://orcid.org/0000-0002-8554-1660)
- Marcela Rezende Lemes (ORCID: https://orcid.org/0000-0001-6393-5880)
- Thaís Cristina Vilela Rodrigues (ORCID: https://orcid.org/0000-0002-2048-5522)
- Felipe Lucas Zen
- Siomar de Castro Soares (ORCID: https://orcid.org/0000-0001-7299-3724)
- Andrei Giacchetto Felice (ORCID: https://orcid.org/0000-0002-8813-8850)
- Carlo José Freire Oliveira (ORCID: https://orcid.org/0000-0003-2211-7333)
- Rafael Obata Trevisan (ORCID: https://orcid.org/0000-0002-4509-9142)
- Vasco Azevedo (ORCID: https://orcid.org/0000-0002-4775-2280)
Institutions
- Universidade Federal de Minas Gerais (BR)
- Universidade Federal da Bahia (BR)
- Southwest Bahia State University (BR)
- Universidade Federal do Triângulo Mineiro (BR)
Publication Details
- Journal
- Memórias do Instituto Oswaldo Cruz
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1590/0074-02760240201
- Citations
- 2
- Primary Topic
- vaccines and immunoinformatics approaches
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais