Immunotherapy in MSS/pMMR Metastatic Colorectal Cancer – Insights from the KEYNOTE-651

Microsatellite stable (MSS)/mismatch repair-proficient (pMMR) colorectal cancer (CRC) accounts for the majority of CRC cases and generally respond poorly to immunotherapy alone. This mini-review integrates findings from the KEYNOTE-651 study with current knowledge of frontline immunotherapy in MSS/pMMR metastatic CRC and explores the implications for clinical practice and future research directions.

Authors

Publication Details

Journal
Journal of Cancer Immunology
Published
2025-01-01
DOI
https://doi.org/10.33696/cancerimmunol.7.100
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
Field-Weighted Citation Impact
0.00
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article

Immunotherapy in MSS/pMMR Metastatic Colorectal Cancer – Insights from the KEYNOTE-651

Richard D. Kim, Raymond Miao
Journal of Cancer Immunology
Cancer Immunotherapy and Biomarkers
article

Immunotherapy in MSS/pMMR Metastatic Colorectal Cancer – Insights from the KEYNOTE-651

Richard D. Kim, Raymond Miao
article en

Abstract

Microsatellite stable (MSS)/mismatch repair-proficient (pMMR) colorectal cancer (CRC) accounts for the majority of CRC cases and generally respond poorly to immunotherapy alone. This mini-review integrates findings from the KEYNOTE-651 study with current knowledge of frontline immunotherapy in MSS/pMMR metastatic CRC and explores the implications for clinical practice and future research directions.

Journal of Cancer ImmunologyVol. 7(1)
Openalex Percentile: Top 92%
Cancer Immunotherapy and Biomarkers
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Immunotherapy in MSS/pMMR Metastatic Colorectal Cancer – Insights from the KEYNOTE-651 — Richard D. Kim, Raymond Miao · Journal of Cancer Immunology (2025) | TGRS Research Map | TGRS