Evaluating the Efficacy of Letrozole and Letrozole-Dexamethasone Combination in Inducing Ovulation in Women with PCOS-Related Subfertility: An Experimental Study

Polycystic ovarian syndrome (PCOS) is a major cause of subfertility in women, frequently requiring ovulation induction treatments. This study evaluated the effectiveness of Letrozole alone versus Letrozole plus Dexamethasone in improving ovulation outcomes in women with PCOS-related subfertility. A randomized controlled trial involved 100 participants split into two groups: Group A received Letrozole alone, and Group B received Letrozole with Dexamethasone. Ultrasound was used to assess follicular diameter and endometrial thickness. Results indicated a significantly greater mean follicular diameter (20.70 ± 4.478 vs. 17.54 ± 3.364, p < .000) and endometrial thickness (6.84 ± 0.997 vs. 5.92 ± 0.922, p < .000) in Group B versus Group A. Dexamethasone appears to enhance ovulation induction by promoting follicular growth and improving endometrial receptivity. The study adds to the evidence supporting the Letrozole-Dexamethasone combination for treating PCOS.