Clinical Correlates of Non-Motor Symptoms and Quality of Life in Parkinson's Disease Patients: Analysis of Motor and Non-Motor Features

Aim: Non-motor symptoms (NMS) significantly impact Parkinson's disease (PD) patients, yet their relationship with disease progression and quality of life requires further investigation. To evaluate the associations between NMS burden, motor symptoms, disease duration, and quality of life in PD patients. Methods: This cross-sectional study included 141 PD patients. NMS were assessed using the NMS Scale. Motor symptoms were evaluated using Unified Parkinson's Disease Rating Scale Part III (UPDRS-III) and Hoehn-Yahr (H&Y) staging. Quality of life was measured using Parkinson's Disease Questionnaire-39 (PDQ-39). Disease duration was categorized into three groups: 9 years. Statistical analyses included correlation coefficients, multivariate logistic regression, and linear regression models. Results: NMS burden strongly correlated with quality of life (r=0.507, p