Erasmus Syndrome—A Rare Cause of Diffuse Cutaneous Systemic Sclerosis due to Silica Exposure: A Case Report

Erasmus syndrome is a rare disease characterized by the development of systemic sclerosis (SSc) in the background of silica exposure or silicosis. Here we report a case of a 42-year-old male who presented with skin tightening for 2 years and progressive dyspnea for 1 year. Patient worked as a sandblaster for 6 months. On examination, there was sclerodactyly, fixed flexion deformity of the lower limbs, diffuse skin tightening and salt and pepper rashes on the chest wall and upper back and crepitations on the chest auscultation. Chest imaging and pulmonary function tests were suggestive of interstitial lung disease. The autoimmune profile showed Scl-70 +++. The diagnosis of erasmus syndrome was made based on specific clinical presentations and characteristic chest imaging findings in a male patient with a history of silica exposure.