Investigating hemodynamic factors and rupture risk in internal carotid artery aneurysms: A computational and statistical analysis

This study investigates the role of hemodynamic factors in assessing rupture risk in intracranial internal carotid artery saccular aneurysms. A total of 24 unruptured and 12 ruptured aneurysms were analyzed using computational fluid dynamics and statistical methods to identify meaningful relationships between hemodynamic parameters and rupture risk. Key metrics, including maximum, mean, and minimum values of blood velocity, and oscillatory shear index (OSI), were statistically compared. The Weibull model was employed to evaluate potential connections between these factors and aneurysm rupture. The spatial distribution of these parameters was mapped on the aneurysm sac surface to identify high-risk regions prone to rupture. Results revealed that ruptured aneurysms exhibit lower maximum blood velocity compared to unruptured ones. Additionally, unruptured aneurysms demonstrated higher maximum OSI values, highlighting a distinct difference in hemodynamic profiles. These findings provide valuable insights into the biomechanical factors influencing aneurysm rupture and may inform clinical risk assessment strategies.