Utilizing dried blood spot micro-sampling and population pharmacokinetic modelling and simulation to inform ampicillin dosing in Chinese neonates
We successfully developed a PopPK model of ampicillin using DBS sampling for Chinese neonates and proposed evidence-based dosing recommendations.
Authors
- Quanyao Chen (ORCID: https://orcid.org/0000-0003-4408-2565)
- Li Rao (ORCID: https://orcid.org/0000-0003-2555-095X)
- Zhi Zheng
- Feifan Xie (ORCID: https://orcid.org/0000-0002-9038-2676)
- Yao Chen (ORCID: https://orcid.org/0000-0001-7231-9860)
- Xiaoyan Zhao (ORCID: https://orcid.org/0000-0003-2468-6767)
- Jianmei Lv
Institutions
- Central South University (CN)
- Xiamen University (CN)
- Xiangya Hospital Central South University (CN)
- Children’s Hospital of Fudan University Xiamen Branch (CN)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1093/jac/dkaf091
- Citations
- 1
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province
- Fundamental Research Funds for Central Universities of the Central South University