Association of opioid and benzodiazepine coprescribing with adverse events among older adults with cancer
Overall, compared with no prescribing, benzodiazepine prescribing and opioid prescribing were each associated with an increase in the immediate risk of adverse events. Effects were similar for those prescribed opioids and those coprescribed opioids/benzodiazepines. For patients with intermittent vs long-term medication exposure, coprescribing additionally increased the risk of overdose and all-cause hospitalization.
Authors
- Amy O’Regan (ORCID: https://orcid.org/0000-0001-6788-5673)
- Samir Soneji (ORCID: https://orcid.org/0000-0001-8735-276X)
- Charles Gaber (ORCID: https://orcid.org/0000-0002-6752-2968)
- Andrea C. Des Marais (ORCID: https://orcid.org/0000-0002-2914-0109)
- Devon K. Check (ORCID: https://orcid.org/0000-0002-0673-879X)
- Katie Fitzgerald Jones (ORCID: https://orcid.org/0000-0002-0825-8394)
- Aaron N. Winn (ORCID: https://orcid.org/0000-0003-2906-3913)
- Lauren E. Wilson (ORCID: https://orcid.org/0000-0002-5953-2293)
- Nicole Fergestrom (ORCID: https://orcid.org/0000-0001-9455-1329)
- Harvey Jay Cohen
- Jessica S. Merlin
Institutions
- Harvard University (US)
- University of Pittsburgh (US)
- Duke University (US)
- VA Boston Healthcare System (US)
- University of Illinois Chicago (US)
- University of Chicago (US)
- VA New England Healthcare System (US)
- Geriatric Research Education and Clinical Center (US)
- Duke Medical Center (US)
- Navitas Systems (United States) (US)
- A123 Systems (United States) (US)
- Duke Cancer Institute
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1093/jnci/djaf072
- Citations
- 3
- Primary Topic
- Palliative Care and End-of-Life Issues
- Type
- article
- Field-Weighted Citation Impact
- 5.64