SARS-Cov-2 vaccination strategies in hospitalized recovered COVID-19 patients: a randomized clinical trial (VATICO Trial)

The impact on immunogenicity and efficacy of SARS-CoV-2 vaccination in people with prior COVID-19 could differ depending on timing of vaccination and number of doses. The VATICO study randomized 66 hospitalized recovered COVID-19 individuals to receive either immediate or deferred vaccination, with one or two doses of mRNA SARS-CoV-2 vaccines. We measured binding and neutralizing antibodies against SARS-CoV-2 at enrollment and longitudinally. Median (IQR) time from SARS-CoV-2 infection to first vaccination was 68 (53-75) days in the immediate group, and 151 (137-173) days in the deferred group. At week 48, timing or number of vaccine doses did not influence the change in antibody levels relative to baseline. Adherence to the assigned vaccine regimen was lower in the deferred group, particularly in participants receiving two doses. Although the study ultimately lacked adequate power to draw firm conclusions, these results suggest possible benefits of prompt vaccination after recovery from COVID-19.

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Journal
Scientific Reports
Published
2025-03-22
DOI
https://doi.org/10.1038/s41598-025-92742-x
Primary Topic
SARS-CoV-2 and COVID-19 Research
Type
article
Field-Weighted Citation Impact
0.00

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SARS-Cov-2 vaccination strategies in hospitalized recovered COVID-19 patients: a randomized clinical trial (VATICO Trial)

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Scientific Reports
SARS-CoV-2 and COVID-19 Research
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SARS-Cov-2 vaccination strategies in hospitalized recovered COVID-19 patients: a randomized clinical trial (VATICO Trial)

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article en

Abstract

The impact on immunogenicity and efficacy of SARS-CoV-2 vaccination in people with prior COVID-19 could differ depending on timing of vaccination and number of doses. The VATICO study randomized 66 hospitalized recovered COVID-19 individuals to receive either immediate or deferred vaccination, with one or two doses of mRNA SARS-CoV-2 vaccines. We measured binding and neutralizing antibodies against SARS-CoV-2 at enrollment and longitudinally. Median (IQR) time from SARS-CoV-2 infection to first vaccination was 68 (53-75) days in the immediate group, and 151 (137-173) days in the deferred group. At week 48, timing or number of vaccine doses did not influence the change in antibody levels relative to baseline. Adherence to the assigned vaccine regimen was lower in the deferred group, particularly in participants receiving two doses. Although the study ultimately lacked adequate power to draw firm conclusions, these results suggest possible benefits of prompt vaccination after recovery from COVID-19.

Scientific ReportsVol. 15(1)
Leidos (United States) (US), Universitat de Vic - Universitat Central de Catalunya (ES), Atrium Health Wake Forest Baptist (US), Cedars-Sinai Medical Center (US), National Institutes of Health (US), University of Minnesota (US), San Francisco VA Medical Center (US), United States Department of Veterans Affairs (US), Duke University (US), University of California, San Francisco (US), King's College London (GB), George Washington University (US), Guy's and St Thomas' NHS Foundation Trust (GB), University of Zurich (CH), University of South Florida (US), Veterans Health Administration (US), Rhode Island Hospital (US), Miriam Hospital (US), Foundation for the National Institutes of Health (US), Instituto de Salud Carlos III (ES), UCLA Medical Center (US), Salem VA Medical Center (US), Lira Hospital (UG), Masaka Hospital (UG), Nsambya Hospital (UG), Tampa General Hospital (US), Denver Health Medical Center (US), Hospital Universitari Arnau de Vilanova (ES), Tan Tock Seng Hospital (SG), Rigshospitalet (DK), Advisory Board Company (United States) (US), Hospital General Universitario Gregorio Marañón (ES), UNSW Sydney (AU), IrsiCaixa (ES), Clinical Research Institute (US), Red de Investigación en Sida (ES), MRC Clinical Trials Unit at UCL (GB), Southwestern Medical Center (US), University Hospital of Zurich (CH), Denver Public Health (US), University Hospital and Clinics (US), Methodist Hospital (US), Public Health Institute (US), CHRISTUS Spohn Hospital Corpus Christi - Memorial (US), Institute of Human Virology (NG), Fundació ACE (ES), Vall d'Hebron Hospital Universitari (ES), Frederick National Laboratory for Cancer Research (US), National Institute of Allergy and Infectious Diseases (US), Washington University Medical Center (US), Minneapolis VA Medical Center (US), Barcelona Institute for Global Health (ES), Gulu Hospital (UG), Duke University Hospital (US), Hospital Universitari Germans Trias i Pujol (ES), Washington DC VA Medical Center (US), Centre of Excellence for Health, Immunity and Infections (DK), Joint Clinical Research Centre (UG), Harbor–UCLA Medical Center (US), Southwestern Medical Center (US), Leidos Biomedical Research Inc. (United States), University College London (GB), Universitat de Barcelona (ES), Makerere University (UG), The University of Texas Southwestern Medical Center (US), Vanderbilt University Medical Center (US), Uganda Virus Research Institute (UG), University of Colorado Denver (US), Stanford University (US), Icahn School of Medicine at Mount Sinai (US)
National Health and Medical Research Council, National Heart, Lung, and Blood Institute
Good health and well-being
Openalex Percentile: Top 92%
SARS-CoV-2 and COVID-19 Research
DOIOpen Access PDFOpenAlex
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