Synonymous Mutations in m⁶A-modified Sites Can Destabilize Tumor Suppressors

Major Finding: Synonymous mutations can promote tumorigenesis by deregulating RNA modifications of tumor suppressors. Concept: Somatic mutations that disrupt m6A sites of tumor suppressors such as BRCA2 and CDKN2A are prevalent in human tumors.Impact: This study sheds light on a common mechanism by which alterations in epitranscriptomic regulation impact tumorigenesis.