Safety and efficacy of antisense oligonucleotides on triglyceride, apolipoprotein C-III, and other lipid parameters levels in hypertriglyceridemia; a network meta-analysis of randomized controlled trials
APOC3 antisense oligonucleotide inhibitors effectively reduced triglyceride and APOC3 levels in hypertriglyceridemia with an acceptable safety profile. However, the results should be interpreted cautiously due to the small sample size. Further research is needed to confirm the beneficial effects of APOC3 inhibitors and show strong evidence of the impact of each regimen.
Authors
- Qasi Najah (ORCID: https://orcid.org/0000-0002-0460-507X)
- Mohamed Riad Abouzid (ORCID: https://orcid.org/0000-0002-4476-5895)
- Basel Abdelazeem (ORCID: https://orcid.org/0000-0002-2919-6196)
- Abdelrahman Mahmoud (ORCID: https://orcid.org/0000-0001-9907-9852)
- James D. Mills (ORCID: https://orcid.org/0000-0002-9910-2933)
- Karim Ali (ORCID: https://orcid.org/0000-0003-4318-8843)
- Shehroze Tabassum (ORCID: https://orcid.org/0000-0002-3115-5545)
- Anas Abdulkader
- Kerollos Abdelsayed (ORCID: https://orcid.org/0009-0001-2499-5570)
- Ahmed Mohamed (ORCID: https://orcid.org/0009-0004-3320-7662)
Institutions
- West Virginia University (US)
- University of Minnesota (US)
- Alfaisal University (SA)
- King Edward Medical University (PK)
- Saint Thomas Midtown Hospital (US)
- Hennepin County Medical Center (US)
- Twin Cities Orthopedics (US)
- University Elmergib (LY)
- Baptist Hospital (US)
- Aswan University (EG)
- Minia University (EG)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1186/s12944-024-02389-2
- Citations
- 9
- Primary Topic
- Lipid metabolism and disorders
- Type
- article
- Field-Weighted Citation Impact
- 12.49