N4-acetylcytidine modification of ITGB5 mRNA mediated by NAT10 promotes perineural invasion in pancreatic ductal adenocarcinoma
Our findings reveal a previously unrecognized ac4C-mediated epigenetic mechanism in PNI and propose a novel therapeutic strategy to improve survival in PDAC patients. NAT10 promotes PNI via ac4C modification in PDAC.
Authors
- Yu Zhou (ORCID: https://orcid.org/0000-0002-2102-9377)
- Rihua He
- Quanbo Zhou (ORCID: https://orcid.org/0000-0001-9554-063X)
- Jianping Liu (ORCID: https://orcid.org/0000-0002-1289-4422)
- Zhiqiang Fu
- Jingwen Li (ORCID: https://orcid.org/0000-0002-5472-9898)
- Jiajia Zhou (ORCID: https://orcid.org/0000-0002-0605-5745)
- Rufu Chen (ORCID: https://orcid.org/0000-0003-4568-1324)
- Leyi Huang (ORCID: https://orcid.org/0000-0001-5311-2741)
- Xiaofeng Guo (ORCID: https://orcid.org/0000-0002-9679-5017)
- Yanan Lu (ORCID: https://orcid.org/0000-0001-7914-9868)
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Guangzhou First People's Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
- South China University of Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1186/s13046-025-03362-2
- Citations
- 8
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 6.45
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province