Proteomic profiling and functional analysis of extracellular vesicles from metastasis-competent circulating tumor cells in colon cancer
This study is a pioneering effort in highlighting therapy progression-associated changes in EVs from mCRC patients via an in vitro CTC model. The results offer insights into the role of metastasis initiator CTC-derived EVs in cancer spread, suggesting their utility for studying cancer tissue distribution mechanisms. However, these findings must be confirmed and extended to patients with mCRC. This work underscores the potential of CTC-derived EVs as tools for understanding cancer dissemination.
Authors
- Luis Enrique Cortés‐Hernández (ORCID: https://orcid.org/0000-0003-2743-1524)
- Catherine Alix‐Panabières (ORCID: https://orcid.org/0000-0002-6401-2903)
- Christophe Hirtz (ORCID: https://orcid.org/0000-0002-7313-0629)
- Bruno Costa‐Silva (ORCID: https://orcid.org/0000-0002-5932-6211)
- Dolores Di Vizio (ORCID: https://orcid.org/0000-0002-9787-6556)
- Laure Cayrefourcq (ORCID: https://orcid.org/0000-0002-6124-7029)
- Sílvia Batista (ORCID: https://orcid.org/0000-0001-8311-8685)
- Zahra Eslami‐S (ORCID: https://orcid.org/0000-0002-3489-2479)
- Aurore Attina (ORCID: https://orcid.org/0009-0001-5261-7438)
- Jérôme Vialeret
Institutions
- Champalimaud Foundation (PT)
- Cedars-Sinai Medical Center (US)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Montpellier (FR)
- Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Gouvernance, Risque, Environnement, Développement (FR)
- Institut de Recherche pour le Développement (FR)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1186/s13046-025-03360-4
- Citations
- 4
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- European Molecular Biology Organization
- Fondation ARC pour la Recherche sur le Cancer
- Institut National Du Cancer
- Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona
- National Institutes of Health
- Horizon 2020