Dysfunctional Breathing and Depression Are Core Extrapulmonary and Behavior/Risk Factor Traits in Type 2–High Severe Asthma
Core extrapulmonary and behavior/risk factor traits in T2-high severe asthma were dysfunctional breathing and depression, contributing to worse asthma outcomes, suggesting that core TTs may differ between asthma inflammatory phenotypes. Elevated systemic inflammation may help in recognizing the presence of dysfunctional breathing and depression in T2-high severe asthma.
Authors
- Vanessa Clark (ORCID: https://orcid.org/0000-0003-3450-5843)
- Peter G. Gibson (ORCID: https://orcid.org/0000-0001-5865-489X)
- Dennis Thomas (ORCID: https://orcid.org/0000-0003-4182-6821)
- Hayley Lewthwaite (ORCID: https://orcid.org/0000-0002-5212-2937)
- Vanessa M. McDonald (ORCID: https://orcid.org/0000-0001-9890-3408)
- Michael Fricker (ORCID: https://orcid.org/0000-0002-8587-1774)
- Yuto Hamada (ORCID: https://orcid.org/0000-0002-3234-652X)
Institutions
- John Hunter Hospital (AU)
- Hunter Medical Research Institute (AU)
Publication Details
- Journal
- The Journal of Allergy and Clinical Immunology In Practice
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1016/j.jaip.2025.03.017
- Citations
- 2
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.33