Positive effect of evobrutinib in CNS remyelination models and lack of synergy with clemastine—A dose response study
While evobrutinib increased 1.59 fold the number of microglia/macrophages, in the presence of clemastine the number of innate immune cells was decreased by 0.39 fold, therefore counteracting the beneficial effect of microglia/macrophages on remyelination.
Authors
- Bruno Stankoff (ORCID: https://orcid.org/0000-0002-9631-4674)
- Marie‐Stéphane Aigrot (ORCID: https://orcid.org/0000-0001-9539-0053)
- Ursula Boschert (ORCID: https://orcid.org/0000-0001-7541-5284)
- Catherine Lubetzki (ORCID: https://orcid.org/0000-0001-7164-3175)
- Elodie Martin (ORCID: https://orcid.org/0000-0001-5668-7516)
- Bernard Zalc (ORCID: https://orcid.org/0000-0002-4683-9827)
- N. Frère
- R. Lepaulmier
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Merck Serono S.A. (Switzerland) (CH)
- Pitié-Salpêtrière Hospital (FR)
- Institut du Cerveau (FR)
- Laboratoire Médiations (FR)
Publication Details
- Journal
- Multiple Sclerosis Journal - Experimental Translational and Clinical
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1177/20552173251326913
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00