NEW DRUGS ON THE PHARMACEUTICAL MARKET CONTAINING FLUORINE AND RESIDUES OF TAILOR-MADE AMINO ACIDS
This article profiles five newly drugs containing fluorine along with fragments of amino acids or their derivatives approved by the FDA in 2024. These pharmaceuticals include Voydeya® (danicopan), Ojemda® (tovorafenib), Itovebi® (inavolisib), Scemblix® (asciminib), and Revuforj® (revumenib). For each drug, we discuss the discovery, therapeutic areas of application, and detailed chemical synthesis.
Authors
- Gagan Dhawan (ORCID: https://orcid.org/0000-0001-7492-225X)
- Daniel Baecker (ORCID: https://orcid.org/0000-0002-1963-9838)
- Vadim A. Soloshonok (ORCID: https://orcid.org/0000-0003-0681-4526)
- Alexander E. Sorochinsky (ORCID: https://orcid.org/0000-0002-0132-2664)
- Alicja Wzorek (ORCID: https://orcid.org/0000-0001-9041-7034)
- Karel D. Klika (ORCID: https://orcid.org/0000-0001-7009-1487)
- Jianlin Han (ORCID: https://orcid.org/0000-0002-3817-0764)
- Wei Zhang (ORCID: https://orcid.org/0000-0002-6097-2763)
- Taizo Ono (ORCID: https://orcid.org/0009-0002-3268-2344)
Institutions
- Boston University (US)
- National Academy of Sciences of Ukraine (UA)
- Nanjing Forestry University (CN)
- University of the Basque Country (ES)
- Jan Kochanowski University (PL)
- University College of Medical Sciences (IN)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University of Massachusetts Boston (US)
- Institute of Bioorganic Chemistry and Petrochemistry V.P. Kukhar (UA)
- National Institute of Advanced Industrial Science and Technology (JP)
- Freie Universität Berlin (DE)
Publication Details
- Journal
- Ukrainian Chemistry Journal
- Published
- 2024-10-25
- DOI
- https://doi.org/10.33609/2708-129x.90.9.2024.31-56
- Citations
- 11
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 2.29