Caffeic Acid Protects Against Ulcerative Colitis via Inhibiting Mitochondrial Apoptosis and Immune Overactivation in Drosophila
CA alleviated intestinal damage mainly by inhibiting the Toll and Imd signaling pathways and inhibiting apoptosis mediated by mitochondrial damage. These findings suggest that CA holds promise as a potential therapeutic for UC treatment.
Authors
- Minghui Xiu (ORCID: https://orcid.org/0000-0002-5338-1586)
- Yongqi Liu (ORCID: https://orcid.org/0000-0003-2090-0017)
- Jianzheng He
- He Li (ORCID: https://orcid.org/0000-0001-7454-0796)
- Youming Zhang (ORCID: https://orcid.org/0000-0001-5403-4044)
- Botong Li (ORCID: https://orcid.org/0009-0008-6561-5627)
- Ningbo Wang (ORCID: https://orcid.org/0000-0002-5530-1885)
- Shihong Zhou (ORCID: https://orcid.org/0000-0002-0723-0293)
- Yan Shi
Institutions
- Qinghai University (CN)
- Gansu University of Traditional Chinese Medicine (CN)
- Qinghai Tibetan Hospital (CN)
- Dunhuang Research Academy (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/dddt.s499284
- Citations
- 9
- Primary Topic
- Parasites and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 18.43