Severe Complicated Secondary Antiphospholipid Syndrome Conjointly with Systemic Lupus Erythematosus – Case Report

Antiphospholipid syndrome (APS), is an autoimmune systemic disorder known to manifest with thrombosis in almost all vessels throughout the body, can also be accompanied by pregnancy morbidity, and is persistent with the presence of antiphospholipid antibodies, including lupus anticoagulant antibodies, or relatively high titers of anticardiolipin, or anti-β2Glycoprotein I antibodies. APS can occur alone or in association with other diseases, more commonly systemic lupus erythematous. In patients with both underlying diseases episodes of arthritis, skin changes in the form of livedo reticularis, thrombocytopenia and leucopenia were more common. Cardiac manifestations have also been reported. Here we present a complicated case of a young female patient with antiphospholipid syndrome and an underlying systemic lupus erythematosus.

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Journal
PRILOZI
Published
2025-03-01
DOI
https://doi.org/10.2478/prilozi-2025-0006
Primary Topic
Systemic Lupus Erythematosus Research
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article
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article

Severe Complicated Secondary Antiphospholipid Syndrome Conjointly with Systemic Lupus Erythematosus – Case Report

Šárka Pavlová, Ana Vasilevska, Filip Gucev, Dubravka Antova et al.
PRILOZI
Systemic Lupus Erythematosus Research
article

Severe Complicated Secondary Antiphospholipid Syndrome Conjointly with Systemic Lupus Erythematosus – Case Report

Šárka Pavlová, Ana Vasilevska, Filip Gucev, Dubravka Antova, Emilija Sandevska, Maja Bojadzioska, Sonja Vidinikj, Ron Vejseli, Anzelika Karadzova-Stojanovska, Ivan Vidinikj
article en

Abstract

Antiphospholipid syndrome (APS), is an autoimmune systemic disorder known to manifest with thrombosis in almost all vessels throughout the body, can also be accompanied by pregnancy morbidity, and is persistent with the presence of antiphospholipid antibodies, including lupus anticoagulant antibodies, or relatively high titers of anticardiolipin, or anti-β2Glycoprotein I antibodies. APS can occur alone or in association with other diseases, more commonly systemic lupus erythematous. In patients with both underlying diseases episodes of arthritis, skin changes in the form of livedo reticularis, thrombocytopenia and leucopenia were more common. Cardiac manifestations have also been reported. Here we present a complicated case of a young female patient with antiphospholipid syndrome and an underlying systemic lupus erythematosus.

PRILOZIVol. 46(1)
University Clinic of Traumatology (AT), Ss. Cyril and Methodius University in Skopje (MK)
Good health and well-being
Openalex Percentile: Top 92%
Systemic Lupus Erythematosus Research
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Severe Complicated Secondary Antiphospholipid Syndrome Conjointly with Systemic Lupus Erythematosus – Case Report — Šárka Pavlová, Ana Vasilevska, et al. · PRILOZI (2025) | TGRS Research Map | TGRS