Riluzole in Combination with mFOLFOX6 and Bevacizumab in Treating Patients with Metastatic Colorectal Cancer: A Phase I Clinical Trial

Our study showed that riluzole plus mFOLFOX6/bevacizumab is well tolerated in patients with metastatic colorectal cancer and may have clinical activity in patients whose disease is resistant to FOLFOX.

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Publication Details

Journal
Clinical Cancer Research
Published
2025-03-20
DOI
https://doi.org/10.1158/1078-0432.ccr-24-3964
Citations
2
Primary Topic
Cancer Treatment and Pharmacology
Type
article
Field-Weighted Citation Impact
2.09
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article

Riluzole in Combination with mFOLFOX6 and Bevacizumab in Treating Patients with Metastatic Colorectal Cancer: A Phase I Clinical Trial

John L. Hays, Anne M. Noonan, Beiyuan Liang, Joo Young Na et al.
2 citations
Clinical Cancer Research
Cancer Treatment and Pharmacology
2.09
article

Riluzole in Combination with mFOLFOX6 and Bevacizumab in Treating Patients with Metastatic Colorectal Cancer: A Phase I Clinical Trial

John L. Hays, Anne M. Noonan, Beiyuan Liang, Joo Young Na, Wayne Miles, Lai Wei, Jing J. Wang, Pannaga Malalur, Arjun Mittra, Ashish Manne, Rifat T. Elkhatib, Ning Jin, Evan H. Zhang, Liwei Yan, Mitch A. Phelps, Shafia Rahman, Sameek Roychowdhury, Hayden Storts, Nicole Abbott, Chunjie Li, Misbah Khan, Vedat Yildiz, Kasey Hill
article en
2 citations

Abstract

Our study showed that riluzole plus mFOLFOX6/bevacizumab is well tolerated in patients with metastatic colorectal cancer and may have clinical activity in patients whose disease is resistant to FOLFOX.

Clinical Cancer ResearchVol. 31(11)
University of Michigan (US), The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US), The Ohio State University Wexner Medical Center (US), The Ohio State University (US)
Good health and well-being
Openalex Percentile: Top 13%
Cancer Treatment and Pharmacology
2.09
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