Multi-wavelength, pathlength selective, interferometric diffuse correlation spectroscopy (Conference Presentation)

Diffuse correlation spectroscopy (DCS) is a noninvasive technique used to estimate tissue blood flow through the analysis of scattered coherent light. While well suited to enable continuous cerebral blood flow monitoring, traditional DCS has limited signal-to-noise ratio (SNR) at source-detector separations sensitive to cerebral physiology. In this work we combine a recently developed advanced DCS technique, pathlength selective interferometric DCS (PaLS-iDCS) with multiwavelength acquisition to allow for the pathlength specific estimation of blood flow, hemoglobin concentration, hemoglobin saturation, and the metabolic rate of oxygen consumption (MRO2). The advances provided by multiwavelength acquisition greatly improve cerebral hemodynamic characterization.