Biological mechanism of retinal damage from exposure to the supercontinuum generated by a NIR femtosecond laser (Conference Presentation)
Ultrashort pulse lasers are currently used in a variety of applications. However, laser safety standards do not consider the potential hazard to the eye due to the nonlinear interaction of ultrashort lasers with the ocular tissues. We used a single NIR femtosecond pulse to determine the peak pulse energies that generated a supercontinuum within the eye of anesthetized porcine subjects and resulted in retinal alterations. Histological analysis of the injuries indicate a photomechanical mechanism of damage. The results of this study inform the laser safety standards about hazards to the eye due to the supercontinuum generated by nonlinear effects in the aqueous media of the eye.
Authors
- Matthew J. Macasadia
- Semih S. Kumru (ORCID: https://orcid.org/0009-0006-1547-7989)
- Harvey M. Hodnett
- Gary D. Noojin (ORCID: https://orcid.org/0009-0006-8311-571X)
- Francesco J. Echeverria (ORCID: https://orcid.org/0000-0001-8421-5380)
- Amanda J. Tijerina (ORCID: https://orcid.org/0009-0008-2597-3243)
- Xomalin G. Peralta (ORCID: https://orcid.org/0000-0002-4034-3214)
- E. Corbin (ORCID: https://orcid.org/0009-0008-8208-387X)
- Amanda M. Peterson (ORCID: https://orcid.org/0009-0004-0275-5666)
- Joseph E. Clary (ORCID: https://orcid.org/0009-0007-9850-2162)
- Maximillian V. Hart (ORCID: https://orcid.org/0009-0002-0373-0896)
- Charles Schwarten (ORCID: https://orcid.org/0009-0004-1059-4970)
- Emily N. Boice
Publication Details
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1117/12.3039279
- Primary Topic
- Ocular and Laser Science Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00