White Matter Differences in Early‐Stage Alcohol Use Disorder: Diffusion Tensor and Neurite Orientation Dispersion and Density Measures of Structural Integrity

These results may represent early-stage neural immune system activation and axonal reorganization targeting frontolimbic and corticostriatal WM tracts, therein associated with behaviours linked to AUD. This is the first study combining DTI and NODDI metrics to identify early-stage indicators of alcohol-related neurobiological pathology in young adults with AUD compared to social drinkers.