The impact of arteriolosclerosis on cognitive impairment in decedents without severe dementia from the National Alzheimer's Coordinating Center
In individuals who do not have severe dementia, vascular neuropathologies are common, and the combination of pathologies is heterogeneous in a convenience sample from the Alzheimer's Disease Research Center that reported all the neuropathology data elements for this investigation. Arteriolosclerosis is associated with several cognitive domain scores, including memory, executive function, and language when controlling for the effects of Alzheimer's disease neuropathologic change and Lewy body disease. These results reinforce the importance of vascular pathology for cognition among people along the Alzheimer's disease spectrum.
Authors
- Jeffrey Nirschl (ORCID: https://orcid.org/0000-0001-6857-341X)
- Carla Abdelnour (ORCID: https://orcid.org/0000-0002-7636-9758)
- Kyan Younes (ORCID: https://orcid.org/0000-0002-9912-1616)
- Alexis Reeves
- Paul K. Crane (ORCID: https://orcid.org/0000-0003-4278-7465)
- Kathleen L. Poston (ORCID: https://orcid.org/0000-0003-3424-7143)
- Cellas A. Hayes (ORCID: https://orcid.org/0000-0002-6259-9456)
- Michelle C. Odden (ORCID: https://orcid.org/0000-0002-5974-3648)
- Elizabeth C. Mormino (ORCID: https://orcid.org/0000-0002-4542-6537)
- Christina B. Young (ORCID: https://orcid.org/0000-0001-9535-2137)
Institutions
- Neurosciences Institute (US)
- University of Washington (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/alz.70059
- Citations
- 11
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 16.18
Funders
- Alzheimer's Association
- Society for Neuroscience
- National Institutes of Health
- School of Medicine, Stanford University
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke