Folate-targeted nanoparticles as drug carriers enhancing the efficiency of 5-Fluorouracil in colorectal cancer cells (Conference Presentation)

In this study, a multimodal imaging system was used to evaluate the efficiency of 5-FU@UIO-66-NH₂ and 5-FU@UIO-66-FA as 5-FU carriers in colorectal cancer（CRC）cells. Two-photon excitation microscopy revealed alterations in the metabolic coenzymes NADH and FAD levels, indicating metabolic shifts occurring in the cells post-nanoparticle treatment. Raman microscopy analyzed CRC cells for alterations in biomarkers and differences in molecular metabolism. The results demonstrated that 5-FU@UIO-66-FA effectively released 5-FU and exhibited a superior inhibitory effect on CRC cell proliferation. This illustrates the potential of multimodal imaging in the analysis of CRC cells with nanoparticle drug delivery, enabling precise molecular and metabolic assessments.